diff --git a/meta-python/recipes-devtools/python/python3-grpcio_1.51.1.bb b/meta-python/recipes-devtools/python/python3-grpcio_1.51.1.bb
index 9a3c3734a..b0971db1c 100644
--- a/meta-python/recipes-devtools/python/python3-grpcio_1.51.1.bb
+++ b/meta-python/recipes-devtools/python/python3-grpcio_1.51.1.bb
@@ -22,7 +22,7 @@ RDEPENDS:${PN} = "${PYTHON_PN}-protobuf \
 inherit setuptools3
 inherit pypi
 
-CFLAGS += "-D_LARGEFILE64_SOURCE"
+CFLAGS:append:libc-musl = " -D_LARGEFILE64_SOURCE"
 
 export GRPC_PYTHON_DISABLE_LIBC_COMPATIBILITY = "1"