diff --git a/meta-python/recipes-core/packagegroups/packagegroup-meta-python.bb b/meta-python/recipes-core/packagegroups/packagegroup-meta-python.bb
index df4fcc882..c6ac19a22 100644
--- a/meta-python/recipes-core/packagegroups/packagegroup-meta-python.bb
+++ b/meta-python/recipes-core/packagegroups/packagegroup-meta-python.bb
@@ -449,7 +449,7 @@ RDEPENDS_packagegroup-meta-python3 = "\
     python3-zopeinterface \
     telepathy-python3 \
 "
-RDEPENDS_packagegroup-meta-python3_remove_powerpc64le = "python3-grpcio python3-grpcio-tools"
+RDEPENDS_packagegroup-meta-python3_remove_libc-musl_powerpc64le = "python3-grpcio python3-grpcio-tools"
 
 RDEPENDS_packagegroup-meta-python3-ptest = "\
     python3-cryptography-ptest \
diff --git a/meta-python/recipes-devtools/python/python3-grpcio-tools_1.35.0.bb b/meta-python/recipes-devtools/python/python3-grpcio-tools_1.35.0.bb
index 475b4e606..6758429ae 100644
--- a/meta-python/recipes-devtools/python/python3-grpcio-tools_1.35.0.bb
+++ b/meta-python/recipes-devtools/python/python3-grpcio-tools_1.35.0.bb
@@ -17,6 +17,6 @@ RDEPENDS_${PN} = "${PYTHON_PN}-grpcio"
 
 BBCLASSEXTEND = "native nativesdk"
 
-# Needs python3-grpcio which does not build for ppc64le
-COMPATIBLE_HOST_powerpc64le = "null"
+# Needs abseil-cpp which does not build for ppc64le/musl
+COMPATIBLE_HOST_libc-musl_powerpc64le = "null"
 
diff --git a/meta-python/recipes-devtools/python/python3-grpcio_1.36.1.bb b/meta-python/recipes-devtools/python/python3-grpcio_1.36.1.bb
index fa030b99e..13cef537e 100644
--- a/meta-python/recipes-devtools/python/python3-grpcio_1.36.1.bb
+++ b/meta-python/recipes-devtools/python/python3-grpcio_1.36.1.bb
@@ -44,6 +44,6 @@ BBCLASSEXTEND = "native nativesdk"
 
 CCACHE_DISABLE = "1"
 
-# abseil-cpp/absl/base/internal/unscaledcycleclock.cc:100:2: error: #error Must implement UnscaledCycleClock::Frequency()
-COMPATIBLE_HOST_powerpc64le = "null"
+# needs vdso support
+COMPATIBLE_HOST_libc-musl_powerpc64le = "null"